Antigen-Free Screening Finds Antibody Biomarkers For Alzheimer's Diagnosis
This article was originally published in Start Up
Executive Summary
Use of a library of synthetic peptide-like molecules as a screen to identify disease-specific antibodies in serum has led to identification of biomarkers for Alzheimer's disease that could form the basis of a blood-based diagnostic test. The screening strategy may also be broadly applicable to the development of diagnostics for other diseases, for identifying antibody targets in autoimmune diseases, and even as the basis for vaccine development.