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ESMO Annual Congress 2024

Read Scrip's analysis of the key news from the conference.

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Featured Stories


ESMO 24: Replimune’s Cancer Vaccine Succeeds In PD-1 Failures

New data suggest that RP1 could become the therapy of choice in melanoma patients who do not respond to checkpoint inhibitors.

Clinical Trials Commercial Companies

ESMO 24: NIAGARA – Trial Design Question Hangs Over Imfinzi’s Bladder Cancer Return

AstraZeneca’s NIAGARA trial of perioperative Imfinzi in bladder cancer was positively received at the ESMO meeting but its design did not distinguish the contributions of each treatment portion to the overall effect – something that the US FDA is likely to have a view on.

ESMO Clinical Trials Companies

MBX, Zenas And Bicara IPOs Generate Big First Day Returns, But Will They Last?

MBX, Zenas and Bicara delivered positive returns in their first days of trading, but that has not always translated to good long-term results for drug developers that launched US IPOs this year.

Financing Growth Strategy

Asia Spotlight

Former Hilleman CEO On Microbiome Project, Cholera, Halal Vaccine

Human milk could have a role in preventing Alzheimer’s disease and other ailments linked to the gut microbiome, says former Pfizer VP and Hilleman CEO Davinder Gill. He also talks about a halal meningitis vaccine, and tailwinds for an oral cholera vaccine now launched by Bharat Biotech in this fascinating interview



Research & Development Vaccines

More coverage from Scrip's team in Asia

Scrip Podcast

Insights and perspectives on commercial, R&D, deal-making and business strategy developments.

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Scrip Originals

Asia Deal Watch: EpimAb Licenses Bispecific Antibody To Newly Formed Vignette

Also including deals between EpimAb/Vignette, Allist/Jacobio, Rigel/Kissei, Simcere/TargetRx, Altamira/Nuance, PharmaEssentia/Forus and Chugai/LTL.

Deal Watch Business Strategies

Executives On The Move: Five New CBOs And Three New CFOs Among This Week's Changes

Recent moves in the industry include changes at the top at LakeShore Biopharma, Atara Biotherapeutics and Defence Therapeutics, plus Transgene gets new chief medical and scientific officers.

Leadership Executive Changes

Finance Watch: Bain Capital Raises $3bn For Fourth Life Sciences Fund

Private Company Edition: Bain will invest across private and public drug, device, diagnostic and tool companies. Also, Candid debuted with $370m in initial funding, Superluminal closed a $120m series A round, PanTera raised €93m ($102.4m) in series A cash and F2G brought in $100m.

Financing Growth

Stock Watch: Regeneron Battles On Two Fronts

As it navigates product transition in ophthalmology against biosimilar and branded rivals, Regeneron seems to have a simpler challenge in another major therapeutic area.

Stock Watch Sales & Earnings
Interviews

Geopolitics, US BIOSECURE: Pharma Looks To Redistribute CDMO Footprint

A redistribution of pharma outsourcing activities, both ex-China and also a wider shift in CDMO work from North America down the line may be in store. A senior McKinsey executive discusses with Scrip these trends in the CDMO sector amid geopolitical tensions, the spurt in customer queries at Indian firms and also facets of the deals scenario.

Commercial Manufacturing

Former Hilleman CEO On Microbiome Project, Cholera, Halal Vaccine

Human milk could have a role in preventing Alzheimer’s disease and other ailments linked to the gut microbiome, says former Pfizer VP and Hilleman CEO Davinder Gill. He also talks about a halal meningitis vaccine, and tailwinds for an oral cholera vaccine now launched by Bharat Biotech in this fascinating interview

Research & Development Vaccines

Hudson Holds Reins As Sanofi Makes Strides To Become R&D Powerhouse

“For 20 or 30 years, we were not seen as a scientific leader,” the French major’s CEO tells Scrip. Now, things have started to change with several positive readouts coming out of its immunology portfolio.

Leadership Business Strategies

AstraZeneca Believes Size Matters In Amyloidosis

Following the pivotal data on Alnylam’s Amvuttra, all eyes turn to the next amyloidosis readout – that of AstraZeneca and Ionis’ Wainua. And the UK major’s ambitions do not stop there.

Clinical Trials Cardiovascular
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Graphics

Progress Or Hype? A Decade Of Cell Therapy In Japan

After 10 years of promised investment following its Nobel Prize for iPS cell research, Japan is cautiously narrowing regulations around the conditional approval of cell therapies and cutting some reimbursement prices. Commercial success remains mixed and some products have been withdrawn from the market.

Japan Policy

Obesity Rules Large-Cap Stocks In First Half Of 2024

Lilly and Novo Nordisk were top performers among large-cap pharma stocks, while the stock prices of Bristol Myers and Gilead declined the most.

Business Strategies Companies

The IPO Queue Fills Up, But A Recovery Is A Way Off

Six biopharma companies have filed to list their shares on US exchanges so far this year, but the sums they are seeking are small.

Financing Commercial

Deal Volume Up, Value Down During The First Half

Without a mega-merger like 2023’s Pfizer/Seagan takeout, M&A deals grew smaller during the first half of 2024, while volume rose. In alliance deals, H1 2024 activity somewhat mirrored activity from H1 2023.

Deals M & A
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Recent Stories

Asia Deal Watch: EpimAb Licenses Bispecific Antibody To Newly Formed Vignette

Also including deals between EpimAb/Vignette, Allist/Jacobio, Rigel/Kissei, Simcere/TargetRx, Altamira/Nuance, PharmaEssentia/Forus and Chugai/LTL.

Deal Watch Business Strategies

ESMO 24: Summit/Akeso Broaden Base Of Solid Tumor Indications For Anti-PD-1xVEGF Bispecific

Phase II data at the ESMO meeting showed promising efficacy for the drug beyond NSCLC, particularly in certain indications of colorectal and head-and-neck cancers.

ESMO ImmunoOncology

Ascendis’ TransCon Positioned To Take On BioMarin’s Voxzogo

The Danish company released pivotal data for TransCon CNP in children with achondroplasia that appears competitive with BioMarin’s big growth driver.

Rare Diseases Clinical Trials

Final Chance To Have Your Say: Take Scrip's Reader Survey This Week

Editor’s note: This is your final call to participate in the survey to better understand our subscribers’ content and delivery needs. The deadline is 20 September.

ESMO 24: Nuvation One Step Ahead In Race For ROS1 Lung Cancer Niche

Two similarly named companies, Nuvation and Nuvalent, are racing to see who can claim best-in-class status in next-generation lung cancer therapies.

Cancer Clinical Trials

ESMO 24: Keytruda Shows Strong OS Benefit In Two Women's Cancers

Merck & Co has presented lots of data on its huge-earning checkpoint inhibitor at the Barcelona congress, the highlights being impressive first-time overall survival results for Keytruda in cervical cancer and early-stage triple-negative breast cancer.

Companies ImmunoOncology

ESMO 24: Incyte’s Zynyz Finally Mounts The POD1UM

Persistence has paid off for Incyte’s Zynyz in anal cancer with a Phase III win that should make up for a previous disappointment at the FDA and give a boost to the firm’s pipeline prospects for a post-Jakafi era.

ESMO Clinical Trials

ESMO 24: GSK and iTeos Chalk Up Much-Needed Win For TIGIT

While oncology heavyweights Roche and Merck & Co have failed to make much headway with their in-house TIGIT offerings, hopes are high for iTeos's belrestotug in combination with GSK's checkpoint inhibitor, Jemperli, which has demonstrated promising response rates for non-small cell lung cancer in the Phase II GALAXIES Lung-201 study.

ImmunoOncology Clinical Trials

Best Practices For Offering Value To Potential Partners – Highlights From LSX

At the 2024 LSX USA conference, panelists provided advice on how to approach companies in dealmaking and to make their value proposition fit with what the company is looking for.

Business Strategies Deals

Roche’s Subcutaneous Ocrevus Could Extend Access To Patients

A subcutaneous formulation of Roche’s best-selling drug will offer an alternative to a lengthy intravenous infusion. Both versions will be priced the same.

Approvals Drug Delivery Technology

Gilead Hits Mark With Second Long-Acting HIV PrEP Trial

The company stands a strong chance of winning approval for lenacapavir as a twice-yearly injectable drug for preventing HIV infection, though market challenges remain.

Infectious Diseases Clinical Trials

Aiming For Keytruda’s Crown, Summit Raises Extra Funds To Fuel Ivonescimab Ambitions

The US company believes it can not only beat Keytruda at its own game, but also achieve success where Merck & Co's blockbuster and other immunotherapies have failed.

Clinical Trials Commercial
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