Tesaro Inc. is moving forward with ambitions to expand the poly ADP-ribose polymerase (PARP) inhibitor Zejula (niraparib) to more indications beyond recurrent ovarian cancer, including as a front-line treatment for ovarian cancer, in combination with the immunotherapy Keytruda (pembrolizumab), in triple-negative breast cancer and lung cancer.
Tesaro's Zejula Expansion Includes Keytruda Combo, Lung Cancer
The company, encouraged by positive Phase I data from a trial testing the PARP inhibitor niraparib in combination with Merck's PD-1 inhibitor Keytruda in recurrent ovarian cancer, plans to initiate a larger trial by the end of the year or early in 2018.
