Champions Biotechnology Inc.'s preclinical screening technology uses xenografts that it creates by implanting primary human cancer tumors into immune-deficient mice. The tumor cells are never passaged in cell tissue culture and therefore maintain the fundamental genotypic features of the original cancer because the risk of mutations through successive generations in culture is eliminated. The company has signed preclinical screening deals with a number of partners and it's also building its own therapeutic pipeline.

Rhenovia Pharma SAS believes it can help companies looking to improve existing Alzheimer's disease therapies by using computational models of the brain to identify chemical combinations capable of positively impacting disease symptoms. The start-up aims to build a service-based business running its specialized "biosimulations" on compounds that other companies currently market, have in development or have previously rejected for lack of efficacy.

Immuneering Corp. is developing mathematical models to predict whether a drug is likely to activate a patient's immune system to aid in fighting cancer and autoimmune diseases. The company's modeling application works with data from patient blood and tumor samples. Immuneering plans to offer its services to drug makers as a way of sorting patients into subpopulations, to understand the workarounds cancers develop against therapies, and to predict efficacy.