This article was originally published in Start Up
Cytox Ltd.'s diagnostics and research services are all based on the cell division cycle theory of Alzheimer's pathogenesis. The firm thinks its diagnostic, a blood test biomarker that measures the integrity of the cell cycle G1/S restriction point in peripheral blood lymphocytes, will detect AD in pre-symptomatic stages and that it can predict which patients suffering from mild cognitive impairment will convert to Alzheimer's. Furthermore, Cytox maintains that its lead program, a neuroblastoma assay, can screen compounds for their potential to affect Alzheimer's disease.
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Rhenovia Pharma SAS believes it can help companies looking to improve existing Alzheimer's disease therapies by using computational models of the brain to identify chemical combinations capable of positively impacting disease symptoms. The start-up aims to build a service-based business running its specialized "biosimulations" on compounds that other companies currently market, have in development or have previously rejected for lack of efficacy.
Immuneering Corp. is developing mathematical models to predict whether a drug is likely to activate a patient's immune system to aid in fighting cancer and autoimmune diseases. The company's modeling application works with data from patient blood and tumor samples. Immuneering plans to offer its services to drug makers as a way of sorting patients into subpopulations, to understand the workarounds cancers develop against therapies, and to predict efficacy.