A Groundswell In Epigenetics
This article was originally published in Start Up
Executive Summary
Two recent papers looking at very different enzymatic activities illustrate how the study of mutation-based alterations in epigenetic mechanisms, and the multiple complex ways in which these alterations reprogram tumor cells, are rapidly advancing both oncology clinical practice and drug development. One identifies a biomarker that would signal the need for aggressive initial leukemia therapy while the other clarifies the mechanism of a drug target in lymphoma.