Seattle Genetics/BMS Blood Cancer Tie-Up May Expand After Good Combo Data
Combo of Seattle Genetics' antibody-drug conjugate Adcetris and BMS's PD-1 inhibitor Opdivo demonstrates 90% objective response rate and 62% complete response rate in relapsed Hodgkin lymphoma, and further investigation of the pairing seems on the cards.
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Regarding FDA filing in new CTCL indication in 2017, Seattle Genetics is hoping for a label that covers all patients, regardless of positivity for CD30, though the Phase III ALCANZA study was done in biomarker expressers.
New data show that Bristol-Myers Squibb Co.'s Opdivo (nivolumab) has promise in treating Hodgkin's lymphoma reinforcing the notion that checkpoint inhibitors have potential in a broad range of cancers.
Part 2: High costs are built into the rare disease business model. Participants at a roundtable discussion led by Scrip at the J.P. Morgan Healthcare Conference talked about how much they are feeling the pressure on pricing.